ciliary neurotrophic factor
- ciliary neurotrophic factor
-
(= CNTF)
Neurotrophin originally characterized as
a survival factor for chick ciliary neurons in vitro. Subsequently shown to promote the survival of
a variety of other neuronal
cell types, and to promote the
differentiation of bipotential
O-2A progenitor cells to type-2 astrocytes in vitro. Developmental expression and regional distribution studies show that, unlike NGF, CNTF is not
a target-derived
neurotrophic factor. Now considered to be one of the
IL-6 cytokine family since it acts through
a receptor containing gp130.
Dictionary of molecular biology.
2004.
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